氧化石墨烯复合纳米材料在抗菌领域应用的研究进展-中国材料进展

文章信息/Info

Title:: Research Progress on Graphene Oxide Nanocomposites in Antibacterial Application

Author(s):: CHENG Zerui; FENG Yonghai; Institute of Advanced Materials，School of Materials Science and Engineering， Jiangsu University，Zhenjiang 212013，China

Keywords:: graphene oxide; nanocomposite; bacterial infection; antibiotic resistance; synergistic effect

摘要:: 由于抗生素的普遍使用和滥用，细菌正在以更快的速度产生耐药性。耐药菌感染给公共医疗卫生提出了严峻的挑战，已造成了大量的死亡和超额的医疗支出。纳米技术的发展有望解决这一难题。在众多抗菌纳米材料中，氧化石墨烯因其特殊的形貌尺寸和物理化学特性而具有多元化的抗菌能力。此外，氧化石墨烯具有超高比表面积、良好的电子传导能力和丰富的表面含氧官能团，是与其他材料复合构建多功能抗菌材料的理想平台，可产生协同抗菌作用。综述了氧化石墨烯及氧化石墨烯基复合抗菌纳米材料研究进展，列举了近年来报道的氧化石墨烯抗菌机制研究进展和存在的挑战，以及常见的氧化石墨烯基复合抗菌纳米材料的最新发展，分析氧化石墨烯在不同材料中对协同抗菌性能起到的关键作用，为开发更高效的氧化石墨烯抗菌纳米材料提供新的思路。

Abstract:: With the widespread and abuse of antibiotics, the drug-resistance of bacteria are becoming much stronger and harder to be conquered. Infections caused by drug-resistant bacteria have posed a serious challenge to public healthcare, which have caused tremendous deaths and excess healthcare expenditures. The development of nanotechnology paves a new way to solve this knotty problem. Among various antimicrobial nanomaterials, graphene oxide has special morphological dimensions and physicochemical properties, which allows it with diverse antimicrobial capabilities. The features of large specific surface area, good electron conductivity and abundant oxygen-containing functional groups on the surface make graphene oxide be an ideal platform for compounding with other antimicrobial materials and acting as a synergistic antimicrobial agent with other antimicrobial nanomaterials. This paper reviews the constructions of antimicrobial nanomaterials based on graphene oxide or graphene oxide-based composite, the mechanisms of antimicrobial effect and recent controversies, as well as the latest development of graphene oxide based antimicrobial composite nanomaterials. Then, we further discuss the key role of graphene oxide in different materials for synergistic antimicrobial properties, and finally provide new ideas for the development of efficient graphene oxide based antimicrobial nanomaterials.