生物医学诊疗用磁性微纳材料-中国材料进展

文章信息/Info

作者:: 蔡晓巍; 阮晓博; 房坤; 杨芳; 顾宁; （1. 东南大学生物电子学国家重点实验室，江苏南京 210009）
（2. 江苏省生物材料与器件重点实验室，江苏南京 210096）

Author(s):: CAI Xiaowei; RUAN Xiaobo; FANG Kun; YANG Fang; GU Ning; (1. State Key Laboratory of Bioelectronics，Southeast University, Nanjing 210009, China)
(2. Jiangsu Key Laboratory for Biomaterials and Devices, Nanjing 210096, China)

摘要:: 磁性微气泡是由包膜微气泡和磁性纳米粒子组成的微纳复合结构，由于其具有超声对比剂和核磁共振对比剂的双重特性，已被应用于双模造影领域。声致穿孔现象（Sonoporation）使得磁性微气泡能介导多种生物学效应，使其在药物输运和基因转染等方面有潜在的应用价值，而磁性微气泡与各种生物分子（抗体、肿瘤标记物等）的偶联，又扩展了磁性微气泡的应用领域，可用于分子影像诊断和靶向治疗肿瘤等方面，可以说磁性微气泡是新一代的生物医学诊疗用磁性微纳材料。总结了磁性微气泡的制备方法，磁性纳米颗粒与微气泡的结合方式，磁性微气泡的功能扩展，以及磁性微气泡在生物医学诊疗领域的实验研究，最后对磁性微气泡在未来的发展方向提出了一些构想，展望了磁性微气泡在诊疗学上广阔的应用前景。

Abstract:: Magnetic microbubble is a micro/nano binary structure composed of encapsulated microbubble and magnetic nanoparticles. Magnetic microbubbles have been used in dualmode imaging for the double properties of ultrasound imaging and magnetic resonance imaging. Sonoporation makes magnetic microbubbles to conduct enormous bioeffects, which have great potential application value in drug delivery and gene transfection. The coupling of magnetic microbubbles to other biomolecules (antibodies, tumor markers and so on) expands the applications of magnetic microbubbles, such as molecular imaging and targeted tumor therapy. So it is proposed that magnetic microbubbles can be potentially applied as a new generation of biological magnetic micro/nano materials for theranostics. This review summarizes the methods to generate magnetic microbubbles, the forms of nanoparticles binding to microbubbles, the functional expanding of magnetic microbubbles and the experimental studies of magnetic microbubbles for biomedical theranostics. In the end, this review raises some ideas of the future development for magnetic microbubbles, and looks forward to the extensive prospects of magnetic microbubbles for theranostics.