[1]王淑芳,郑文婷,孔德领.体内组织工程构建小口径人工血管的研究进展[J].中国材料进展,2012,(9):006-15.[doi:10.7502/j.issn.1674-3962.2012.09.02]
　WANG Shufang,ZHENG Wenting,KONG Deling.The Development of Construction of Small Diameter Vascular Grafts in Vivo[J].MATERIALS CHINA,2012,(9):006-15.[doi:10.7502/j.issn.1674-3962.2012.09.02]
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体内组织工程构建小口径人工血管的研究进展()
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中国材料进展[ISSN:1674-3962/CN:61-1473/TG]

卷:
期数:
2012年第9期
页码:
006-15
栏目:
特约研究论文
出版日期:
2012-09-30

文章信息/Info

Title:
The Development of Construction of Small Diameter Vascular Grafts in Vivo
作者:
王淑芳; 郑文婷; 孔德领
(南开大学生命科学学院 药物化学生物学国家重点实验室，天津 300071)
Author(s):
WANG Shufang;  ZHENG Wenting;  KONG Deling
(State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China)
关键词:
人工血管; 组织工程; 支架制备; 干细胞捕捉; 内皮化; 平滑肌再生; 细胞外微环境
DOI:
10.7502/j.issn.1674-3962.2012.09.02
文献标志码:
A
摘要:
小口径血管在临床上有很大需求，但小口径血管再狭窄率很高。体内组织工程是改善小口径血管功能、实现血管再生的有效手段。介绍了小口径人工血管的国内外研究发展动态，详述了作者实验室在构建小口径人工血管方面的设计思路和研究所取得的主要进展。研究包括支架材料结构设计与制备技术，支架材料表面功能化修饰，内皮祖细胞捕捉，血管平滑肌再生，抗凝血和促内皮细胞黏附，血管再生微环境的构建等。最后对小口径人工血管研究尚需解决的科学问题和研究方向进行了讨论。
Abstract:
Although there is a growing demand of small diameter vascular grafts for cardiovascular disease, the incidence rate of restenosis caused by vascular grafts remains high. An effective approach to improve the function of smalldiameter vascular grafts and realize the blood vessel regeneration would be to induce a healing response in vivo for tissue engineering. In this article, we summarize the recent research developments on smalldiameter vascular grafts, and highlight the main designing ideas and research outcomes in our laboratory. The work includes structural design and fabrication of porous scaffolds, anticlotting modification, functionalization for endothelial progenitor cells (EPCs) capture, creation of microenvironment for vascular smooth muscle regeneration and angiogenesis. Some directions and problems on future research in these areas are also discussed.
更新日期/Last Update: 2012-09-21