壳聚糖对骨组织工程中组织修复的影响-中国材料进展

文章信息/Info

Author(s):: JIAO Yanpeng; LI Lihua; LUO Binghong; ZHOU Changren; (Department of Materials Science and Engineering, Jinan University, Guangzhou 510632，China)

摘要:: 材料植入体内必然引起宿主体的应答，促进或抑制组织愈合。由于降解材料在体内的降解产物会随时间而变，产生的宿主体应答就会不同，进而会影响组织的愈合。而促进或抑制组织愈合的机制就成为新型医用高分子材料设计和制备的理论基础。壳聚糖是理想的骨组织修复材料之一，但至今还不清楚壳聚糖体内不同降解过程对组织修复的影响机制，也就无法设计出性能优良的壳聚糖基新材料。文章没有罗列壳聚糖基生物材料在骨组织工程中应用所取得的进展，而是重点阐述了壳聚糖在骨组织工程中应用的复杂性和对组织修复的影响，探讨了壳聚糖进一步用于骨组织工程所需要解决的问题。

Abstract:: Materials implanted in the body would inevitably lead to host response, promoting or inhibiting tissue healing. The degradation products of biodegradable materials in the body will change with time, resulting in different host responses and further affecting tissue healing. Therefore, the mechanism of promoting or inhibiting tissue healing becomes the theoretical basis for the design and preparation of novel biomedical polymer materials. Chitosan is one of the ideal medical polymer materials, but we still do not know the effect mechanism of chitosan degradation process on tissue repair in vivo. So it will not be able to design chitosanbased materials with excellent performance. This review does not lay out the progress of the chitosanbased biomaterials applied in bone tissue engineering, but focuses on the complexity of chitosan applications for bone tissue engineering, furthermore investigates the problems needed to be solved for chitosan used in bone tissue engineering.