可降解金属血管支架研究进展-中国材料进展

文章信息/Info

作者:: 吴远浩; 周晓晨; 李楠; 郑玉峰; （1.北京大学前沿交叉学科研究院生物医用材料与组织工程中心，北京 100871）
（2.北京大学工学院材料科学与工程系，北京100871）

Author(s):: WU Yuanhao; ZHOU Xiaochen; LI Nan; ZHENG Yufeng; (1 Center for Biomedical Materials and Tissue Engineering, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China)
(2 Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China)

摘要:: 随着心血管疾病治疗技术的发展，各种金属血管支架作为治疗心血管疾病的最有效器械之一，已经越来越受到人们的关注。重点介绍了目前研究最广泛的2类可降解金属血管支架材料：镁基合金和铁基合金。总结了这2类血管支架用可降解金属材料的研究进展，血管支架器械的动物试验和临床试验研究成果。归纳了可降解金属血管支架的有限元结构设计、应力分析、体内体外降解性能和生物相容性等需要重点考虑的属性。指出了可降解金属血管支架目前存在的不足，并对可降解金属血管支架未来的研究方向和发展前景进行了展望。

Abstract:: With the development of new technology to treat cardiovascular disease (CVD), cardiovascular stents have drawn more and more attention as one of the most effective device in the treatment of CVD. In this paper, we mainly focused on two types of biodegradable metallic vascular stents which are mostly investigated nowadays,namely magnesium alloy stents and iron based alloy stents. We summarized the research progresses on these biodegradable metallic alloys from the viewpoint of materials science in the present days and the animal experiments, clinic trail results of their stents as well. We overviewed about the finite element design, stress analysis, mechanical property, degradation performance, biocompatibility of the biodegradable metallic stents. Finally, we pointed out the deficiency of current biodegradable metallic stent and their future research direction.