合成水凝胶材料在组织工程中的应用<br />-中国材料进展

文章信息/Info

作者:: 刘水莲1; 宿烽1; 李速明2; （1.青岛科技大学高性能聚合物研究院，山东青岛266042）
（2.法国蒙彼利埃二大欧洲薄膜研究院，蒙彼利埃 34095）

Author(s):: LIU Shuilian1; SU Feng1; LI Suming2; 1.Institute of High Performance Polymers, Qingdao University of Science and Technology, Qingdao 266042,China)
（ 2.Institut Europeen des Membranes, UMR CNRS 5635, Universite Montpellier II, Montpellier 34095)

摘要:: 水凝胶材料因其高保湿、高吸水等特点，在组织工程、生物医药等领域具有广阔的现实意义和应用前景，特别是作为药物缓释剂、组织填充剂、酶的包埋剂、人造皮肤等方面。按原料来源分，水凝胶材料可分为天然水凝胶材料和合成水凝胶材料。尽管天然水凝胶材料的生物相容性、生物降解性优于合成水凝胶材料，但合成水凝胶材料具有相对较高的机械性能，备受研究者青睐。近年来，如何将两种类型的水凝胶材料的优点结合在一起应用成为研究热点。大量关于水凝胶材料的改性研究相继开展，并取得了一定进展。主要概述了以聚乙二醇、聚乙烯醇、聚丙烯酰胺为基础合成的水凝胶材料的研究及发展状况，并对几种水凝胶材料进行了初步生物学评价，探讨了此类水凝胶在组织工程中的应用。

Abstract:: Hydrogels have practical significance and broad application prospects in the field of tissue engineering , biomedicine, etc, especially as drug delivery agents, tissue filling agent, enzymeembedding agent and artificial skin, because of their high moisturizing ability and high water absorption. It can be divided into two types according to their raw material source, natural hydrogels and synthetic hydrogels. Although natural hydrogels have better biocompatibility, biodegradability than synthetic hydrogels, synthetic hydrogel materials have relatively high mechanical properties that attract researchers’ eyes. In recent years, it has become a research hotpot to combine the benefits of two types. A lot of researches on modification of hydrogels have emerged one after another, and some progress has made. This paper reviews the researches, development, biological evaluation of synthetic hydrogels based on poly(ethylene glycol), poly(vinyl alcohol), and polyacrylamide. Peculiar attention is paid to the applications in tissue engineering.