生物医用抗菌性硅橡胶的研究进展-中国材料进展

文章信息/Info

Title:: Research Development of the Biological Medical Silicone Rubber with Antimicrobial Properties

Author(s):: LIU Fang; HU Chen; State Key Laboratory for Powder Metallurgy, Central South University

摘要:: 硅橡胶高分子材料具有优良的特性,如耐高温、耐老化、透明度高，并且无毒无味、机械性能以及生物相容性好，因而广泛应用于生物学、医学等领域。然而随着医疗水平的提高，人们对医用制品的要求也越来越严格。硅橡胶植入生物体后易造成相关细菌感染，限制了其临床应用。生物研究表明，通过表面改性和本体改性的方法，在硅橡胶中添加抗菌剂，可有效提高其抗菌性能, 抑制细菌的繁殖、防止二次感染的发生。通过对抗菌剂种类、含量等控制，可以使加工成型的液体或者固体硅橡胶保持原有的硫化和物理机械性能。通过总结国内外的研究成果，分析了各种生物医用抗菌性硅橡胶材料，对其制备工艺、抗菌性能和应用情况等进行了阐述，同时也展望了新的研究思路。

Abstract:: The polymer material of silicone rubber has good properties, such as heat resistance, aging resistance, high transparency, avirulence, odorless, excellent mechanical property and biocompatibility. These kinds of materials are widely used in biological and medical fields. However, with the improvement of health standards, the demands for medical products continue to increase. Implanted into organisms, silicone rubber is likely to get infected by germs, which limits the clinical application of the materials. Some biological researchers show that, added antibacterial agent by surface modification and ontology modification, the antimicrobial properties of silicone rubber increase obviously. The addition of the antibacterial agents can inhibit microbial growth and prevent secondary infection. Controlling the types and contents of the antibacterial agents, the molding liquid silicone rubber or solid silicone rubber can keep original vulcanization, physical and mechanical properties. In this paper, preparation technology, antibacterial properties and application of antibacterial silicon rubbers are summarized. A new research idea is also discussed.