半导体光热转换纳米材料的研究进展-中国材料进展

文章信息/Info

作者:: 王兆洁; 余诺; 孟周琪; 刘子潇; MACHARIA Daniel K.; 胡俊青; 陈志钢; 东华大学材料科学与工程学院，纤维材料改性国家重点实验室

Author(s):: WANG Zhaojie; YU Nuo; MENG Zhouqi; LIU Zixiao; MACHARIA Daniel K.; HU Junqing; CHEN Zhigang; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University

Keywords:: cancer; photothermal therapy; photothermal agent; semiconductor; multifunction

摘要:: 癌症已成为严重威胁人们健康的头号杀手，传统的癌症治疗技术存在很多的局限和不足，所以亟需开发一种新型的治疗技术。目前，近红外光驱动的光热消融治疗已经被认为是一种有效的癌症治疗技术，该技术的发展关键是研发高效且生物相容性好的光热转换试剂。半导体光热转换试剂具有价格低廉、光热转换效率高等优点，引起了广泛关注。本文总结了近年来半导体光热转换试剂的研究进展，主要包括铜基（CuS, Cu9S5和CuSe等）和钨基（W18O49, CsxWO3和WS2等）半导体。另外，还介绍了半导体多功能光热试剂（如G-CuS-DOX和FeS2-350等）在化疗/热疗或者成像/治疗一体化方面的进展。最后，指出了目前存在的问题和发展方向。

Abstract:: Cancer is a worldwide leading cause of death. Conventional therapeutic techniques for cancers have some obvious limitations and are unsatisfactory, thus it is very necessary to develop new therapy technology. Recently, near-infrared (NIR) laser-induced photothermal ablation therapy (PAT) has been demonstrated to have great potential to cure tumors, and a prerequisite is to obtain biocompatible and efficient photothermal agents. Among all the photothermal agents, semiconductor-based photothermal nanoagents have attracted increasing interest due to their low cost and high photothermal conversion efficiency. This review attempts to summarize the recent progress in the rational design and fabrication of semiconductor photothermal nanoagents, including Cu-based (CuS, Cu9S5 and CuSe) and W-based (W18O49, CsxWO3 and WS2) nanomaterials. Furthermore, the semiconductor-based multifunction nanoagents (such as G-CuS-DOX, FeS2-350) are also summarized for the development of synergic photothermal/chemo-therapy or imaging-guided photothermal therapy. This review ends with a summary and some perspectives on the challenges and new directions in this exciting and still emerging area of research.