新型含铜金属心血管支架材料-中国材料进展

文章信息/Info

Author(s):: YANG Ke; REN Ling; Institute of Metal Research，Chinese Academy of Sciences

Keywords:: Cu-bearing metal; coronary stent; biofunction; in-stent restenosis

摘要:: 针对心血管支架内再狭窄问题（ISR），作者团队利用Cu元素对心血管系统的有益生物功能，创新地发展出具有生物功能的新型含铜血管支架材料（含铜不锈钢及钴基合金）。综述了近年来团队在新型含铜金属血管支架材料方面的研究进展。研究结果表明，含铜金属血管支架材料能促进内皮细胞增殖及迁移，并降低其凋亡率；对动脉平滑肌增殖及迁移具有抑制作用，并促进其凋亡；减少血小板在支架表面的粘附，延长动态凝血时间，降低血栓形成倾向。此外，新型含铜金属血管支架材料还具有有优异的生物相容性。动物实验结果表明，含铜不锈钢心血管支架在动物体内可明显促进内皮化、抑制血栓形成，且生物相容性好，可以抑制ISR的发生，有望得到临床应用。

Abstract:: In view of the in-stent restenosis (ISR) problem in clinic, the team led by Prof. Ke Yang in the Institute of Metal Research, Chinese Academy of Sciences has developed a new class of Cu-bearing metal materials for stent application (316L-Cu stainless steel and L605-Cu cobalt based alloy). This paper reviews the recent advances of the research team regarding this new class of Cu-bearing metal stent materials. The experimental results showed that these Cu-bearing metal stent materials can effectively promote the proliferation and migration of endothelial cells and decrease the apoptosis rate, whereas on the contrary inhibite the proliferation and migration of arterial smooth muscle and promote its apoptosis. More than this, they also can reduce the adhesion of platelets on the metal surface, prolong the dynamic coagulation time, and thus reduced the tendency of thrombosis. In addition, the new stent materials also have excellent biocompatibility. The in vivo studies show that the Cu-bearing stainless steel stent implantation in animals have excellent biocompatibility and can obviously promote endothelialization, inhibit thrombosis, and ultimately inhibit the occurrence of ISR. Consequently, these new Cu-bearing metal materials are expected to be a new generation coronary stent materials with the function of reducing occurrence of ISR.