[1]刘绘龙,田磊,孙文森,等.基于3D打印树脂模具的注塑聚醚醚酮下颌骨植入物的初步临床应用研究[J].中国材料进展,2023,42(12):1001-1008.[doi:10.7502/j.issn.1674-3962.202206002]
 LIU Huilong,TIAN Lei,SUN Wensen,et al.Preliminary Clinical Application Research of Personalized PEEK Mandibular Implant Injected with 3D Printed Resin Mold[J].MATERIALS CHINA,2023,42(12):1001-1008.[doi:10.7502/j.issn.1674-3962.202206002]
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基于3D打印树脂模具的注塑聚醚醚酮下颌骨植入物的初步临床应用研究()
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中国材料进展[ISSN:1674-3962/CN:61-1473/TG]

卷:
42
期数:
2023年第12期
页码:
1001-1008
栏目:
出版日期:
2023-12-31

文章信息/Info

Title:
Preliminary Clinical Application Research of Personalized PEEK Mandibular Implant Injected with 3D Printed Resin Mold
文章编号:
1674-3962(2023)12-1001-08
作者:
刘绘龙1田磊2孙文森3秦勉3陈若梦4吴艳1王春雨1刘彦普2刘亚雄5
1.郑州大学第一附属医院医学3D打印中心,河南 郑州 4500522.空军军医大学第三附属医院口腔颌面外科,陕西 西安 7100323.西安交通大学 机械制造系统工程国家重点实验室,陕西 西安7100494.唐山学院 河北省智能装备数字化设计及过程仿真重点实验室,河北 唐山 0630005.季华实验室,广东 佛山 528200
Author(s):
LIU Huilong1 TIAN Lei2 SUN Wensen3 QIN Mian3 CHEN Ruomeng4WU Yan1 WANG Chunyu1LIU Yanpu2 LIU Yaxiong 5
1. Medical 3D Printing Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China2. Department of Oral and Maxillofacial Surgery,The Third Hospital of Air Force Military Medical University,Xi‘an 710032, China3. State Key Laboratory for Manufacturing Systems Engineering,Xi’an Jiaotong University, Xi‘an 710049, China.et al.
关键词:
3D打印树脂模具聚醚醚酮注塑临床应用
Keywords:
3D printing resin mold polyetheretherketone (PEEK) injection moldingclinical application
分类号:
TB324;R782.2
DOI:
10.7502/j.issn.1674-3962.202206002
文献标志码:
A
摘要:
为了促进基于光固化3D打印模具注塑工艺成型的个性化聚醚醚酮(poly-etherether-ketone, PEEK)植入物的临床应用,首先对PEEK下颌骨植入物与骨骼的装配安全性进行了评估,然后采用体外细胞毒性实验对PEEK原材料和PEEK注塑成型植入物材料进行生物相容性表征,最后采用该工艺方案制造出个性化PEEK全颞下颌关节,并联合数字化正颌外科技术成功治疗了一例严重“半侧颜面短小综合征”患者。研究结果表明,PEEK下颌骨植入物的设计厚度应不小于2 mm;该工艺方案所使用的PEEK原材料对细胞无毒害作用,而且在整个工艺过程中没有引入新的有毒物质;一次手术实现了颞下颌关节重建、下颌骨缺损修复和偏颌畸形的精确矫正,手术效果好、手术安全、患者满意度高。因此,采用3D打印树脂模具个性化注塑成型PEEK下颌骨植入物是治疗重度“半侧颜面短小综合征”的有效方法,本研究为个性化PEEK植入物在临床的广泛应用奠定了基础。
Abstract:
In order to promote the clinical application of personalized poly-ether-ether-ketone (PEEK) implant formed by 3D printing technology of stereolithography and injection molding process, the assembly safety between PEEK mandibular implant and bone was evaluated, and then the biocompatibility characterization of PEEK raw material and PEEK injection molded implant material were tested by in vitro cytotoxicity test. Finally, personalized PEEK total temporomandibular joint prostheses were manufactured by using injection molding with 3D printed resin mold, and a patient with severe hemifacial shortness syndrome was successfully treated in combination with digital orthognathic surgery. The results show that, the design thickness of PEEK mandibular implant should not be less than 2 mm; the PEEK raw material used in the process has no toxic effect on cells, and no new toxic substances is introduced in the whole process; one operation realizes the reconstruction of temporomandibular joint, the repair of mandibular defect and the accurate correction of partial jaw deformity; the operation has good effect, operation safety and high patient satisfaction. Therefore, personalized PEEK mandibular implant injected with 3D printed resin mold is an effective method for the treatment of severe hemifacial shortness syndrome, this study lays a foundation for the wider clinic application of personalized PEEK implants.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2022-06-02修回日期:2022-09-27基金项目:国家自然科学基金资助项目(52075421);广东省基础与应用基础研究基金项目(2020B1515130002);季华实验室项目(X200031TM200)第一作者:刘绘龙,男,1993年生,助理工程师通讯作者:刘亚雄,男,1964年生,教授,博士生导师,Email:yaxiongliu@163.com;刘彦普,男,1957年生,主任医师,博士生导师,Email:liuyanpu@fmmu.edu.cn
更新日期/Last Update: 2023-11-28