(1. Key Laboratory of Polymer Synthesis and Functional Structure, Ministry of Education, Hangzhou 310027, China) (2. Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China)
Polydopamine (PDA), as the most typical melanin analog, possesses excellent antioxidant activity and biocompatibility. These unique properties make PDA-based nanomaterials widely concerned in the fields of inflammation treatment, wound repair and biomimetic material preparation. Although great progress has been made, the antioxidant mechanism of PDA-based nanomaterials remains unclear. In this review, we summarize and discuss the important research progress of PDA-based nanomaterials in anti-oxidation in recent years. In the first section, we introduce the synthesis and antioxidant mechanism of PDA-based nanomaterials. In the second section, we summarize the regulation of its antioxidant properties mainly from three aspects: particle size, microstructure and redox degree. In the third section, we summarize the antioxidant properties of PDA-based nanomaterials for biomedical applications. Finally, we discuss the challenges and future development prospects of PDA-based nanomaterials. We hope that this review can provide ideas and references for the design and development of PDA-based nanomaterials with antioxidant functions.