(1.Nanomedicine and Biosensor Laboratory, Harbin Institute of Technology, Harbin 150080, China) (2.Department of Biomedical Engineering, Peking University, Beijing 100871, China)
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DOI:
10.7502/j.issn.1674-3962.2012.06.03
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Abstract:
Cancer is a highly heterogeneous and adaptable disease, therefore, diverse types of treatment options need to be chosen depending on patient characteristics and disease progression. Theranostic nanoparticles provide patients with various treatment options that are suitable for individuals, and thereby result in improved prognosis. So it is important to develop novel multifunctional nanotheranostic agents. Commonly used diagnostic agents and treatment methods were introduced, such as diagnostic agents including Xray computed tomography contrast agents, ultrasound contrast agents, MRI contrast agents and positron emission tomography imaging agents. Treatment methods include chemotherapy, radiotherapy, photodynamic therapy, photothermal therapy and gene therapy. A variety of typical nanotheranostic agents reported in recent years were reviewed, and the problems existed in the studies of theranostics and the possibly future development direction were also proposed.